Role of the WNK-activated SPAK kinase in regulating blood pressure
Mutations within the with-no-K(Lys) (WNK) kinases cause Gordon's syndrome characterized by hypertension and hyperkalaemia. WNK kinases phosphorylate and activate the STE20/SPS1-related proline/alanine-rich kinase (SPAK) protein kinase, which phosphorylates and stimulates the key Na+:Cl− cotrans...
Main Authors: | , , , , , , , , |
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Format: | Online |
Language: | English |
Published: |
WILEY-VCH Verlag
2010
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377268/ |