Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome, which is characterized by cleft palate and severe defects of the skin, is an autosomal dominant disorder caused by mutations in the gene encoding transcription factor p63. Here, we report the generation of a knock-in mouse model for...

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Bibliographic Details
Main Authors: Ferone, Giustina, Thomason, Helen A, Antonini, Dario, De Rosa, Laura, Hu, Bing, Gemei, Marica, Zhou, Huiqing, Ambrosio, Raffaele, Rice, David P, Acampora, Dario, van Bokhoven, Hans, Del Vecchio, Luigi, Koster, Maranke I, Tadini, Gianluca, Spencer-Dene, Bradley, Dixon, Michael, Dixon, Jill, Missero, Caterina
Format: Online
Language:English
Published: WILEY-VCH Verlag 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376849/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376849/

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