A reporter system for replication-competent gammaretroviruses: the inGluc-MLV-DERSE assay

While novel retroviral vectors for use in gene-therapy products are reducing the potential for formation of replication-competent retrovirus (RCR), it remains crucial to screen products for RCR for both research and clinical purposes. For clinical grade gammaretrovirus-based vectors, RCR screening i...

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Bibliographic Details
Main Authors: Aloia, Amanda L., Duffy, Lisa, Pak, Vladimir, Lee, KyeongEun, Sanchez-Martinez, Silvia, Derse, David, Heidecker, Gisela, Cornetta, Kenneth, Rein, Alan
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374051/