Detectable clonal mosaicism and its relationship to aging and cancer

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls drawn from 13 genome-wide association studies (GWAS), we observed large chromosomal abnormalities in a subset of clones from DNA obtained from blood or buccal samples. Mosaic chromosomal abnormalities, either aneuploidy or copy-ne...

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Main Authors: Jacobs, Kevin B, Yeager, Meredith, Zhou, Weiyin, Wacholder, Sholom, Wang, Zhaoming, Rodriguez-Santiago, Benjamin, Hutchinson, Amy, Deng, Xiang, Liu, Chenwei, Horner, Marie-Josephe, Cullen, Michael, Epstein, Caroline G, Burdett, Laurie, Dean, Michael C, Chatterjee, Nilanjan, Sampson, Joshua, Chung, Charles C, Kovaks, Joseph, Gapstur, Susan M, Stevens, Victoria L, Teras, Lauren T, Gaudet, Mia M, Albanes, Demetrius, Weinstein, Stephanie J, Virtamo, Jarmo, Taylor, Philip R, Freedman, Neal D, Abnet, Christian C, Goldstein, Alisa M, Hu, Nan, Yu, Kai, Yuan, Jian-Min, Liao, Linda, Ding, Ti, Qiao, You-Lin, Gao, Yu-Tang, Koh, Woon-Puay, Xiang, Yong-Bing, Tang, Ze-Zhong, Fan, Jin-Hu, Aldrich, Melinda C, Amos, Christopher, Blot, William J, Bock, Cathryn H, Gillanders, Elizabeth M, Harris, Curtis C, Haiman, Christopher A, Henderson, Brian E, Kolonel, Laurence N, Le Marchand, Loic, McNeill, Lorna H, Rybicki, Benjamin A, Schwartz, Ann G, Signorello, Lisa B, Spitz, Margaret R, Wiencke, John K, Wrensch, Margaret, Wu, Xifeng, Zanetti, Krista A, Ziegler, Regina G, Figueroa, Jonine D, Garcia-Closas, Montserrat, Malats, Nuria, Marenne, Gaelle, Prokunina-Olsson, Ludmila, Baris, Dalsu, Schwenn, Molly, Johnson, Alison, Landi, Maria Teresa, Goldin, Lynn, Consonni, Dario, Bertazzi, Pier Alberto, Rotunno, Melissa, Rajaraman, Preetha, Andersson, Ulrika, Freeman, Laura E Beane, Berg, Christine D, Buring, Julie E, Butler, Mary A, Carreon, Tania, Feychting, Maria, Ahlbom, Anders, Gaziano, J Michael, Giles, Graham G, Hallmans, Goran, Hankinson, Susan E, Hartge, Patricia, Henriksson, Roger, Inskip, Peter D, Johansen, Christoffer, Landgren, Annelie, McKean-Cowdin, Roberta, Michaud, Dominique S, Melin, Beatrice S, Peters, Ulrike, Ruder, Avima M, Sesso, Howard D, Severi, Gianluca, Shu, Xiao-Ou, Visvanathan, Kala, White, Emily, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Silverman, Debra T, Kogevinas, Manolis, Gonzalez, Juan R, Villa, Olaya, Li, Donghui, Duell, Eric J, Risch, Harvey A, Olson, Sara H, Kooperberg, Charles, Wolpin, Brian M, Jiao, Li, Hassan, Manal, Wheeler, William, Arslan, Alan A, Bas Bueno-de-Mesquita, H, Fuchs, Charles S, Gallinger, Steven, Gross, Myron D, Holly, Elizabeth A, Klein, Alison P, LaCroix, Andrea, Mandelson, Margaret T, Petersen, Gloria, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Canzian, Federico, Chang, Kenneth, Cotterchio, Michelle, Giovannucci, Edward L, Goggins, Michael, Bolton, Judith A Hoffman, Jenab, Mazda, Khaw, Kay-Tee, Krogh, Vittorio, Kurtz, Robert C, McWilliams, Robert R, Mendelsohn, Julie B, Rabe, Kari G, Riboli, Elio, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Elena, Joanne W, Yu, Herbert, Amundadottir, Laufey, Stolzenberg-Solomon, Rachael Z, Kraft, Peter, Schumacher, Fredrick, Stram, Daniel, Savage, Sharon A, Mirabello, Lisa, Andrulis, Irene L, Wunder, Jay S, García, Ana Patiño, Sierrasesúmaga, Luis, Barkauskas, Donald A, Gorlick, Richard G, Purdue, Mark, Chow, Wong-Ho, Moore, Lee E, Schwartz, Kendra L, Davis, Faith G, Hsing, Ann W, Berndt, Sonja I, Black, Amanda, Wentzensen, Nicolas, Brinton, Louise A, Lissowska, Jolanta, Peplonska, Beata, McGlynn, Katherine A, Cook, Michael B, Graubard, Barry I, Kratz, Christian P, Greene, Mark H, Erickson, Ralph L, Hunter, David J, Thomas, Gilles, Hoover, Robert N, Real, Francisco X, Fraumeni, Joseph F, Caporaso, Neil E, Tucker, Margaret, Rothman, Nathaniel, Pérez-Jurado, Luis A, Chanock, Stephen J
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372921/