Detection of allele-specific methylation through a generalized heterogeneous epigenome model

Motivations: High-throughput sequencing has made it possible to sequence DNA methylation of a whole genome at the single-base resolution. A sample, however, may contain a number of distinct methylation patterns. For instance, cells of different types and in different developmental stages may have di...

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Bibliographic Details
Main Authors: Peng, Qian, Ecker, Joseph R.
Format: Online
Language:English
Published: Oxford University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371863/