Human Metapneumovirus Genetic Variability, South Africa

The molecular epidemiology and genetic diversity of the human metapneumovirus (hMPV) were characterized for a 3-year period (2000–2002) from viruses that were identified in South Africa. Two major genetic groups (A and B) and 2 subgroups (1 and 2) of hMPV were identified, as well as 2–6 possible gen...

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Main Authors:	Ludewick, Herbert P., Abed, Yacine, van Niekerk, Nadia, Boivin, Guy, Klugman, Keith P., Madhi, Shabir A.
Format:	Online
Language:	English
Published:	Centers for Disease Control and Prevention 2005
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371776/

id	pubmed-3371776
recordtype	oai_dc
spelling	pubmed-33717762012-06-19 Human Metapneumovirus Genetic Variability, South Africa Ludewick, Herbert P. Abed, Yacine van Niekerk, Nadia Boivin, Guy Klugman, Keith P. Madhi, Shabir A. Research The molecular epidemiology and genetic diversity of the human metapneumovirus (hMPV) were characterized for a 3-year period (2000–2002) from viruses that were identified in South Africa. Two major genetic groups (A and B) and 2 subgroups (1 and 2) of hMPV were identified, as well as 2–6 possible genotypes within the subgroups. A shift in the predominant group was documented in successive seasons. Whereas the F gene was relatively conserved between subgroups, a high degree of variation was observed in the extracellular domain of the G gene of the virus. The G protein identities between groups A and B were 45.1%–53.1% at the nucleotide level and 22.4%–27.6% at the amino acid level. These results provide evidence for the diversity of both surface glycoproteins of hMPV in Africa, which may be a prerequisite to understanding protective immunity against hMPV. Centers for Disease Control and Prevention 2005-07 /pmc/articles/PMC3371776/ /pubmed/16022783 http://dx.doi.org/10.3201/eid1107.050500 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ludewick, Herbert P. Abed, Yacine van Niekerk, Nadia Boivin, Guy Klugman, Keith P. Madhi, Shabir A.
spellingShingle	Ludewick, Herbert P. Abed, Yacine van Niekerk, Nadia Boivin, Guy Klugman, Keith P. Madhi, Shabir A. Human Metapneumovirus Genetic Variability, South Africa
author_facet	Ludewick, Herbert P. Abed, Yacine van Niekerk, Nadia Boivin, Guy Klugman, Keith P. Madhi, Shabir A.
author_sort	Ludewick, Herbert P.
title	Human Metapneumovirus Genetic Variability, South Africa
title_short	Human Metapneumovirus Genetic Variability, South Africa
title_full	Human Metapneumovirus Genetic Variability, South Africa
title_fullStr	Human Metapneumovirus Genetic Variability, South Africa
title_full_unstemmed	Human Metapneumovirus Genetic Variability, South Africa
title_sort	human metapneumovirus genetic variability, south africa
description	The molecular epidemiology and genetic diversity of the human metapneumovirus (hMPV) were characterized for a 3-year period (2000–2002) from viruses that were identified in South Africa. Two major genetic groups (A and B) and 2 subgroups (1 and 2) of hMPV were identified, as well as 2–6 possible genotypes within the subgroups. A shift in the predominant group was documented in successive seasons. Whereas the F gene was relatively conserved between subgroups, a high degree of variation was observed in the extracellular domain of the G gene of the virus. The G protein identities between groups A and B were 45.1%–53.1% at the nucleotide level and 22.4%–27.6% at the amino acid level. These results provide evidence for the diversity of both surface glycoproteins of hMPV in Africa, which may be a prerequisite to understanding protective immunity against hMPV.
publisher	Centers for Disease Control and Prevention
publishDate	2005
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371776/
_version_	1611535688708128768

Human Metapneumovirus Genetic Variability, South Africa

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