Loss of Ercc1 Results in a Time- and Dose-Dependent Reduction of Proliferating Early Hematopoietic Progenitors

Loss of Ercc1 Results in a Time- and Dose-Dependent Reduction of Proliferating Early Hematopoietic Progenitors

The endonuclease complex Ercc1/Xpf is involved in interstrand crosslink repair and functions downstream of the Fanconi pathway. Loss of Ercc1 causes hematopoietic defects similar to those seen in Fanconi Anemia. Ercc1 −/− mice die 3-4 weeks after birth, which prevents long-term follow up of the hema...

Full description

Bibliographic Details
Main Authors: Verhagen-Oldenampsen, Judith H. E., Haanstra, Jurgen R., van Strien, Paulina M. H., Valkhof, Marijke, Touw, Ivo P., von Lindern, Marieke
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371671/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371671/

Similar Items