The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure
Background. Medical comorbidity has been theorized to contribute to cognitive impairment in heart failure (HF) patients. Specifically, type-2 diabetes mellitus (T2DM), a common coexisting condition among HF patients, may be an independent predictor of cognitive impairment. Nonetheless, the relation...
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Hindawi Publishing Corporation
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371669/ |
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pubmed-33716692012-06-13 The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure Alosco, Michael L. Spitznagel, Mary Beth van Dulmen, Manfred Raz, Naftali Cohen, Ronald Sweet, Lawrence H. Colbert, Lisa H. Josephson, Richard Hughes, Joel Rosneck, Jim Gunstad, John Research Article Background. Medical comorbidity has been theorized to contribute to cognitive impairment in heart failure (HF) patients. Specifically, type-2 diabetes mellitus (T2DM), a common coexisting condition among HF patients, may be an independent predictor of cognitive impairment. Nonetheless, the relationships between T2DM and other risk factors for cognitive impairment among persons with HF are unclear. Methods. Persons with HF (N = 169, 34.3% women, age 68.57 ± 10.28 years) completed neuropsychological testing within a framework of an ongoing study. History of T2DM, along with other medical characteristics, was ascertained through a review of participants' medical charts and self-report. Results. Many participants (34.9%) had a comorbid T2DM diagnosis. After adjustment for demographic and medical characteristics, HF patients with T2DM evidenced significantly greater impairments across multiple cognitive domains than HF patients without T2DM: λ = .92, F(5, 156) = 2.82, P = .018. Post hoc tests revealed significant associations between T2DM and attention (P = .003), executive function (P = .032), and motor functioning (P = .008). Conclusion. The findings suggest additive contributions of T2DM and HF to impairments in attention, executive function, and motor function. Future work is needed to elucidate the mechanisms by which T2DM exacerbates cognitive impairment in HF. Hindawi Publishing Corporation 2012 2012-06-03 /pmc/articles/PMC3371669/ /pubmed/22701196 http://dx.doi.org/10.1155/2012/348054 Text en Copyright © 2012 Michael L. Alosco et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Alosco, Michael L. Spitznagel, Mary Beth van Dulmen, Manfred Raz, Naftali Cohen, Ronald Sweet, Lawrence H. Colbert, Lisa H. Josephson, Richard Hughes, Joel Rosneck, Jim Gunstad, John |
| spellingShingle |
Alosco, Michael L. Spitznagel, Mary Beth van Dulmen, Manfred Raz, Naftali Cohen, Ronald Sweet, Lawrence H. Colbert, Lisa H. Josephson, Richard Hughes, Joel Rosneck, Jim Gunstad, John The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure |
| author_facet |
Alosco, Michael L. Spitznagel, Mary Beth van Dulmen, Manfred Raz, Naftali Cohen, Ronald Sweet, Lawrence H. Colbert, Lisa H. Josephson, Richard Hughes, Joel Rosneck, Jim Gunstad, John |
| author_sort |
Alosco, Michael L. |
| title |
The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure |
| title_short |
The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure |
| title_full |
The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure |
| title_fullStr |
The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure |
| title_full_unstemmed |
The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure |
| title_sort |
additive effects of type-2 diabetes on cognitive function in older adults with heart failure |
| description |
Background. Medical comorbidity has been theorized to contribute to cognitive impairment in heart failure (HF) patients. Specifically, type-2 diabetes mellitus (T2DM), a common coexisting condition among HF patients, may be an independent predictor of cognitive impairment. Nonetheless, the relationships between T2DM and other risk factors for cognitive impairment among persons with HF are unclear. Methods. Persons with HF (N = 169, 34.3% women, age 68.57 ± 10.28 years) completed neuropsychological testing within a framework of an ongoing study. History of T2DM, along with other medical characteristics, was ascertained through a review of participants' medical charts and self-report. Results. Many participants (34.9%) had a comorbid T2DM diagnosis. After adjustment for demographic and medical characteristics, HF patients with T2DM evidenced significantly greater impairments across multiple cognitive domains than HF patients without T2DM: λ = .92, F(5, 156) = 2.82, P = .018. Post hoc tests revealed significant associations between T2DM and attention (P = .003), executive function (P = .032), and motor functioning (P = .008). Conclusion. The findings suggest additive contributions of T2DM and HF to impairments in attention, executive function, and motor function. Future work is needed to elucidate the mechanisms by which T2DM exacerbates cognitive impairment in HF. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371669/ |
| _version_ |
1611535649845805056 |