Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8
Mutation of the p53 gene is the most common genetic alteration in human cancer and contributes to malignant process by enhancing transformed properties of cells and resistance to anticancer therapy. Mutant p53 is often highly expressed in tumor cells at least in part due to its increased half-life....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371110/ |