Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

A high-throughput screen against PknB, an essential serine–threonine protein kinase present in Mycobacterium tuberculosis (M. tuberculosis), allowed the identification of an aminoquinazoline inhibitor which was used as a starting point for SAR investigations. Although a significant improvement in en...

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Bibliographic Details
Main Authors: Chapman, Timothy M., Bouloc, Nathalie, Buxton, Roger S., Chugh, Jasveen, Lougheed, Kathryn E.A., Osborne, Simon A., Saxty, Barbara, Smerdon, Stephen J., Taylor, Debra L., Whalley, David
Format: Online
Language:English
Published: Elsevier Science Ltd 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368261/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368261/

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