The SNARE Machinery in Mast Cell Secretion
Mast cells are known as inflammatory cells which exert their functions in allergic and anaphylactic reactions by secretion of numerous inflammatory mediators. During an allergic response, the high-affinity IgE receptor, FcεRI, becomes cross-linked by receptor-bound IgE and antigen resulting in immed...
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Frontiers Research Foundation
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367400/ |
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pubmed-33674002012-06-07 The SNARE Machinery in Mast Cell Secretion Lorentz, Axel Baumann, Anja Vitte, Joana Blank, Ulrich Immunology Mast cells are known as inflammatory cells which exert their functions in allergic and anaphylactic reactions by secretion of numerous inflammatory mediators. During an allergic response, the high-affinity IgE receptor, FcεRI, becomes cross-linked by receptor-bound IgE and antigen resulting in immediate release of pre-synthesized mediators – stored in granules – as well as in de novo synthesis of various mediators like cytokines and chemokines. Soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptors (SNARE) proteins were found to play a central role in regulating membrane fusion events during exocytosis. In addition, several accessory regulators like Munc13, Munc18, Rab GTPases, secretory carrier membrane proteins, complexins, or synaptotagmins were found to be involved in membrane fusion. In this review we summarize our current knowledge about the SNARE machinery and its mechanism of action in mast cell secretion. Frontiers Research Foundation 2012-06-05 /pmc/articles/PMC3367400/ /pubmed/22679448 http://dx.doi.org/10.3389/fimmu.2012.00143 Text en Copyright © 2012 Lorentz, Baumann, Vitte and Blank. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lorentz, Axel Baumann, Anja Vitte, Joana Blank, Ulrich |
| spellingShingle |
Lorentz, Axel Baumann, Anja Vitte, Joana Blank, Ulrich The SNARE Machinery in Mast Cell Secretion |
| author_facet |
Lorentz, Axel Baumann, Anja Vitte, Joana Blank, Ulrich |
| author_sort |
Lorentz, Axel |
| title |
The SNARE Machinery in Mast Cell Secretion |
| title_short |
The SNARE Machinery in Mast Cell Secretion |
| title_full |
The SNARE Machinery in Mast Cell Secretion |
| title_fullStr |
The SNARE Machinery in Mast Cell Secretion |
| title_full_unstemmed |
The SNARE Machinery in Mast Cell Secretion |
| title_sort |
snare machinery in mast cell secretion |
| description |
Mast cells are known as inflammatory cells which exert their functions in allergic and anaphylactic reactions by secretion of numerous inflammatory mediators. During an allergic response, the high-affinity IgE receptor, FcεRI, becomes cross-linked by receptor-bound IgE and antigen resulting in immediate release of pre-synthesized mediators – stored in granules – as well as in de novo synthesis of various mediators like cytokines and chemokines. Soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptors (SNARE) proteins were found to play a central role in regulating membrane fusion events during exocytosis. In addition, several accessory regulators like Munc13, Munc18, Rab GTPases, secretory carrier membrane proteins, complexins, or synaptotagmins were found to be involved in membrane fusion. In this review we summarize our current knowledge about the SNARE machinery and its mechanism of action in mast cell secretion. |
| publisher |
Frontiers Research Foundation |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367400/ |
| _version_ |
1611534661203263488 |