Disulfide Bridges Remain Intact while Native Insulin Converts into Amyloid Fibrils

Amyloid fibrils are β-sheet-rich protein aggregates commonly found in the organs and tissues of patients with various amyloid-associated diseases. Understanding the structural organization of amyloid fibrils can be beneficial for the search of drugs to successfully treat diseases associated with pro...

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Bibliographic Details
Main Authors: Kurouski, Dmitry, Washington, Jacqueline, Ozbil, Mehmet, Prabhakar, Rajeev, Shekhtman, Alexander, Lednev, Igor K.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365881/