Genome-wide meta-analyses of smoking behaviors in African Americans

The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco...

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Main Authors:	David, S P, Hamidovic, A, Chen, G K, Bergen, A W, Wessel, J, Kasberger, J L, Brown, W M, Petruzella, S, Thacker, E L, Kim, Y, Nalls, M A, Tranah, G J, Sung, Y J, Ambrosone, C B, Arnett, D, Bandera, E V, Becker, D M, Becker, L, Berndt, S I, Bernstein, L, Blot, W J, Broeckel, U, Buxbaum, S G, Caporaso, N, Casey, G, Chanock, S J, Deming, S L, Diver, W R, Eaton, C B, Evans, D S, Evans, M K, Fornage, M, Franceschini, N, Harris, T B, Henderson, B E, Hernandez, D G, Hitsman, B, Hu, J J, Hunt, S C, Ingles, S A, John, E M, Kittles, R, Kolb, S, Kolonel, L N, Le Marchand, L, Liu, Y, Lohman, K K, McKnight, B, Millikan, R C, Murphy, A, Neslund-Dudas, C, Nyante, S, Press, M, Psaty, B M, Rao, D C, Redline, S, Rodriguez-Gil, J L, Rybicki, B A, Signorello, L B, Singleton, A B, Smoller, J, Snively, B, Spring, B, Stanford, J L, Strom, S S, Swan, G E, Taylor, K D, Thun, M J, Wilson, A F, Witte, J S, Yamamura, Y, Yanek, L R, Yu, K, Zheng, W, Ziegler, R G, Zonderman, A B, Jorgenson, E, Haiman, C A, Furberg, H
Format:	Online
Language:	English
Published:	Nature Publishing Group 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365260/

id	pubmed-3365260
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spelling	pubmed-33652602012-06-01 Genome-wide meta-analyses of smoking behaviors in African Americans David, S P Hamidovic, A Chen, G K Bergen, A W Wessel, J Kasberger, J L Brown, W M Petruzella, S Thacker, E L Kim, Y Nalls, M A Tranah, G J Sung, Y J Ambrosone, C B Arnett, D Bandera, E V Becker, D M Becker, L Berndt, S I Bernstein, L Blot, W J Broeckel, U Buxbaum, S G Caporaso, N Casey, G Chanock, S J Deming, S L Diver, W R Eaton, C B Evans, D S Evans, M K Fornage, M Franceschini, N Harris, T B Henderson, B E Hernandez, D G Hitsman, B Hu, J J Hunt, S C Ingles, S A John, E M Kittles, R Kolb, S Kolonel, L N Le Marchand, L Liu, Y Lohman, K K McKnight, B Millikan, R C Murphy, A Neslund-Dudas, C Nyante, S Press, M Psaty, B M Rao, D C Redline, S Rodriguez-Gil, J L Rybicki, B A Signorello, L B Singleton, A B Smoller, J Snively, B Spring, B Stanford, J L Strom, S S Swan, G E Taylor, K D Thun, M J Wilson, A F Witte, J S Yamamura, Y Yanek, L R Yu, K Zheng, W Ziegler, R G Zonderman, A B Jorgenson, E Haiman, C A Furberg, H Original Article The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527[A]) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (β=0.040, s.e.=0.007, P=1.84 × 10−8). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans. Nature Publishing Group 2012-05 2012-05-22 /pmc/articles/PMC3365260/ /pubmed/22832964 http://dx.doi.org/10.1038/tp.2012.41 Text en Copyright © 2012 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	David, S P Hamidovic, A Chen, G K Bergen, A W Wessel, J Kasberger, J L Brown, W M Petruzella, S Thacker, E L Kim, Y Nalls, M A Tranah, G J Sung, Y J Ambrosone, C B Arnett, D Bandera, E V Becker, D M Becker, L Berndt, S I Bernstein, L Blot, W J Broeckel, U Buxbaum, S G Caporaso, N Casey, G Chanock, S J Deming, S L Diver, W R Eaton, C B Evans, D S Evans, M K Fornage, M Franceschini, N Harris, T B Henderson, B E Hernandez, D G Hitsman, B Hu, J J Hunt, S C Ingles, S A John, E M Kittles, R Kolb, S Kolonel, L N Le Marchand, L Liu, Y Lohman, K K McKnight, B Millikan, R C Murphy, A Neslund-Dudas, C Nyante, S Press, M Psaty, B M Rao, D C Redline, S Rodriguez-Gil, J L Rybicki, B A Signorello, L B Singleton, A B Smoller, J Snively, B Spring, B Stanford, J L Strom, S S Swan, G E Taylor, K D Thun, M J Wilson, A F Witte, J S Yamamura, Y Yanek, L R Yu, K Zheng, W Ziegler, R G Zonderman, A B Jorgenson, E Haiman, C A Furberg, H
spellingShingle	David, S P Hamidovic, A Chen, G K Bergen, A W Wessel, J Kasberger, J L Brown, W M Petruzella, S Thacker, E L Kim, Y Nalls, M A Tranah, G J Sung, Y J Ambrosone, C B Arnett, D Bandera, E V Becker, D M Becker, L Berndt, S I Bernstein, L Blot, W J Broeckel, U Buxbaum, S G Caporaso, N Casey, G Chanock, S J Deming, S L Diver, W R Eaton, C B Evans, D S Evans, M K Fornage, M Franceschini, N Harris, T B Henderson, B E Hernandez, D G Hitsman, B Hu, J J Hunt, S C Ingles, S A John, E M Kittles, R Kolb, S Kolonel, L N Le Marchand, L Liu, Y Lohman, K K McKnight, B Millikan, R C Murphy, A Neslund-Dudas, C Nyante, S Press, M Psaty, B M Rao, D C Redline, S Rodriguez-Gil, J L Rybicki, B A Signorello, L B Singleton, A B Smoller, J Snively, B Spring, B Stanford, J L Strom, S S Swan, G E Taylor, K D Thun, M J Wilson, A F Witte, J S Yamamura, Y Yanek, L R Yu, K Zheng, W Ziegler, R G Zonderman, A B Jorgenson, E Haiman, C A Furberg, H Genome-wide meta-analyses of smoking behaviors in African Americans
author_facet	David, S P Hamidovic, A Chen, G K Bergen, A W Wessel, J Kasberger, J L Brown, W M Petruzella, S Thacker, E L Kim, Y Nalls, M A Tranah, G J Sung, Y J Ambrosone, C B Arnett, D Bandera, E V Becker, D M Becker, L Berndt, S I Bernstein, L Blot, W J Broeckel, U Buxbaum, S G Caporaso, N Casey, G Chanock, S J Deming, S L Diver, W R Eaton, C B Evans, D S Evans, M K Fornage, M Franceschini, N Harris, T B Henderson, B E Hernandez, D G Hitsman, B Hu, J J Hunt, S C Ingles, S A John, E M Kittles, R Kolb, S Kolonel, L N Le Marchand, L Liu, Y Lohman, K K McKnight, B Millikan, R C Murphy, A Neslund-Dudas, C Nyante, S Press, M Psaty, B M Rao, D C Redline, S Rodriguez-Gil, J L Rybicki, B A Signorello, L B Singleton, A B Smoller, J Snively, B Spring, B Stanford, J L Strom, S S Swan, G E Taylor, K D Thun, M J Wilson, A F Witte, J S Yamamura, Y Yanek, L R Yu, K Zheng, W Ziegler, R G Zonderman, A B Jorgenson, E Haiman, C A Furberg, H
author_sort	David, S P
title	Genome-wide meta-analyses of smoking behaviors in African Americans
title_short	Genome-wide meta-analyses of smoking behaviors in African Americans
title_full	Genome-wide meta-analyses of smoking behaviors in African Americans
title_fullStr	Genome-wide meta-analyses of smoking behaviors in African Americans
title_full_unstemmed	Genome-wide meta-analyses of smoking behaviors in African Americans
title_sort	genome-wide meta-analyses of smoking behaviors in african americans
description	The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527[A]) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (β=0.040, s.e.=0.007, P=1.84 × 10−8). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans.
publisher	Nature Publishing Group
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365260/
_version_	1611534182824017920

Genome-wide meta-analyses of smoking behaviors in African Americans

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