Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer

Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer

The objective of the current study was to investigate the expression pattern and clinicopathological significance of TRIM24 in patients with non-small cell lung cancer (NSCLC). The expression profile of TRIM24 in NSCLC tissues and adjacent noncancerous lung tissues was detected by immunohistochemist...

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Main Authors: Li, Haiying, Sun, Liangliang, Tang, Zhongping, Fu, Lin, Xu, Ying, Li, Zixuan, Luo, Wenting, Qiu, Xueshan, Wang, Enhua
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364288/
id pubmed-3364288
recordtype oai_dc
spelling pubmed-33642882012-06-04 Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer Li, Haiying Sun, Liangliang Tang, Zhongping Fu, Lin Xu, Ying Li, Zixuan Luo, Wenting Qiu, Xueshan Wang, Enhua Research Article The objective of the current study was to investigate the expression pattern and clinicopathological significance of TRIM24 in patients with non-small cell lung cancer (NSCLC). The expression profile of TRIM24 in NSCLC tissues and adjacent noncancerous lung tissues was detected by immunohistochemistry. TRIM24 was found to be overexpressed in 81 of 113 (71.7%) human lung cancer samples and correlated with p-TNM stage (p  = 0.0006), poor differentiation (p = 0.004), Ki67 index (p<0.0001), cyclin D1(p = 0.0096) and p-Rb expression (p = 0.0318). In addition, depleting TRIM24 expression by small interfering RNA inhibited growth and invasion in lung cell lines. Moreover, TRIM24 depletion induced cell cycle arrest at the G1/S boundary and induced apoptosis. Western blotting analysis revealed that knockdown of TRIM24 decreased the protein levels of Cyclin A, Cyclin B, Cyclin D1, cyclin E and p-Rb and increased P27 expression. These results indicate that TRIM24 plays an important role in NSCLC progression. Public Library of Science 2012-05-30 /pmc/articles/PMC3364288/ /pubmed/22666376 http://dx.doi.org/10.1371/journal.pone.0037657 Text en Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Li, Haiying
Sun, Liangliang
Tang, Zhongping
Fu, Lin
Xu, Ying
Li, Zixuan
Luo, Wenting
Qiu, Xueshan
Wang, Enhua
spellingShingle Li, Haiying
Sun, Liangliang
Tang, Zhongping
Fu, Lin
Xu, Ying
Li, Zixuan
Luo, Wenting
Qiu, Xueshan
Wang, Enhua
Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
author_facet Li, Haiying
Sun, Liangliang
Tang, Zhongping
Fu, Lin
Xu, Ying
Li, Zixuan
Luo, Wenting
Qiu, Xueshan
Wang, Enhua
author_sort Li, Haiying
title Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_short Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_full Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_fullStr Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_full_unstemmed Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_sort overexpression of trim24 correlates with tumor progression in non-small cell lung cancer
description The objective of the current study was to investigate the expression pattern and clinicopathological significance of TRIM24 in patients with non-small cell lung cancer (NSCLC). The expression profile of TRIM24 in NSCLC tissues and adjacent noncancerous lung tissues was detected by immunohistochemistry. TRIM24 was found to be overexpressed in 81 of 113 (71.7%) human lung cancer samples and correlated with p-TNM stage (p  = 0.0006), poor differentiation (p = 0.004), Ki67 index (p<0.0001), cyclin D1(p = 0.0096) and p-Rb expression (p = 0.0318). In addition, depleting TRIM24 expression by small interfering RNA inhibited growth and invasion in lung cell lines. Moreover, TRIM24 depletion induced cell cycle arrest at the G1/S boundary and induced apoptosis. Western blotting analysis revealed that knockdown of TRIM24 decreased the protein levels of Cyclin A, Cyclin B, Cyclin D1, cyclin E and p-Rb and increased P27 expression. These results indicate that TRIM24 plays an important role in NSCLC progression.
publisher Public Library of Science
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364288/
_version_ 1611533838433910784

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