Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion

The activity state of E-cadherin is controlled by conformational epitopes at interfaces between different EC domains, which are coupled to p120-catenin phosphorylation. Dephosphorylation activates adhesion, whereas phosphorylation inhibits activation. p120-dependent changes in the physical state of...

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Bibliographic Details
Main Authors: Petrova, Yuliya I., Spano, MarthaJoy M., Gumbiner, Barry M.
Format: Online
Language:English
Published: The American Society for Cell Biology 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364174/