NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains

Tumor metastasis is the primary cause of death in cancer patients, but the molecular mechanisms driving the evolution of the phenotype toward a specific organ is one of its less understood aspects. The scaffolding protein NHERF1 reprograms the metastatic phenotype and organotropism via the different...

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Bibliographic Details
Main Authors: Cardone, Rosa Angela, Greco, Maria Raffaella, Capulli, Mattia, Weinman, Edward J., Busco, Giovanni, Bellizzi, Antonia, Casavola, Valeria, Antelmi, Ester, Ambruosi, Barbara, Dell'Aquila, Maria Elena, Paradiso, Angelo, Teti, Anna, Rucci, Nadia, Reshkin, Stephan Joel
Format: Online
Language:English
Published: The American Society for Cell Biology 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364169/