Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity

Stroke is a major neurological disorder characterized by an increase in the Glu (glutamate) concentration resulting in excitotoxicity and eventually cellular damage and death in the brain. HIF-1 (hypoxia-inducible factor-1), a transcription factor, plays an important protective role in promoting cel...

Full description

Bibliographic Details
Main Authors: Badawi, Yomna, Ramamoorthy, Prabhu, Shi, Honglian
Format: Online
Language:English
Published: American Society for Neurochemistry 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363983/