The Yeast Ubr1 Ubiquitin Ligase Participates in a Prominent Pathway That Targets Cytosolic Thermosensitive Mutants for Degradation
Mutations causing protein misfolding and proteolysis are associated with many genetic diseases. The degradation of these aberrant proteins typically is mediated by protein-quality control pathways that recognize misfolded domains. Several E3 ubiquitin ligases have been shown to target cytosolic misf...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Genetics Society of America
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362944/ |