Mdm2 RING Mutation Enhances p53 Transcriptional Activity and p53-p300 Interaction

Mdm2 RING Mutation Enhances p53 Transcriptional Activity and p53-p300 Interaction

The p53 transcription factor and tumor suppressor is regulated primarily by the E3 ubiquitin ligase Mdm2, which ubiquitinates p53 to target it for proteasomal degradation. Aside from its ubiquitin ligase function, Mdm2 has been believed to be capable of suppressing p53's transcriptional activit...

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Bibliographic Details
Main Authors: Clegg, Hilary V., Itahana, Yoko, Itahana, Koji, Ramalingam, Sundhar, Zhang, Yanping
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362553/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362553/

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