Ocular Manifestations of Alzheimer's Disease in Animal Models
Alzheimer's disease (AD) is the most common form of dementia, and the pathological changes of senile plaques (SPs) and neurofibrillary tangles (NFTs) in AD brains are well described. Clinically, a diagnosis remains a postmortem one, hampering both accurate and early diagnosis as well as researc...
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| Format: | Online |
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Hindawi Publishing Corporation
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362039/ |
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pubmed-33620392012-06-04 Ocular Manifestations of Alzheimer's Disease in Animal Models Parnell, Miles Guo, Li Abdi, Mohamed Cordeiro, M. Francesca Review Article Alzheimer's disease (AD) is the most common form of dementia, and the pathological changes of senile plaques (SPs) and neurofibrillary tangles (NFTs) in AD brains are well described. Clinically, a diagnosis remains a postmortem one, hampering both accurate and early diagnosis as well as research into potential new treatments. Visual deficits have long been noted in AD patients, and it is becoming increasingly apparent that histopathological changes already noted in the brain also occur in an extension of the brain; the retina. Due to the optically transparent nature of the eye, it is possible to image the retina at a cellular level noninvasively and thus potentially allow an earlier diagnosis as well as a way of monitoring progression and treatment effects. Transgenic animal models expressing amyloid precursor protein (APP) presenilin (PS) and tau mutations have been used successfully to recapitulate the pathological findings of AD in the brain. This paper will cover the ocular abnormalities that have been detected in these transgenic AD animal models. Hindawi Publishing Corporation 2012 2012-05-15 /pmc/articles/PMC3362039/ /pubmed/22666623 http://dx.doi.org/10.1155/2012/786494 Text en Copyright © 2012 Miles Parnell et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Parnell, Miles Guo, Li Abdi, Mohamed Cordeiro, M. Francesca |
| spellingShingle |
Parnell, Miles Guo, Li Abdi, Mohamed Cordeiro, M. Francesca Ocular Manifestations of Alzheimer's Disease in Animal Models |
| author_facet |
Parnell, Miles Guo, Li Abdi, Mohamed Cordeiro, M. Francesca |
| author_sort |
Parnell, Miles |
| title |
Ocular Manifestations of Alzheimer's Disease in Animal Models |
| title_short |
Ocular Manifestations of Alzheimer's Disease in Animal Models |
| title_full |
Ocular Manifestations of Alzheimer's Disease in Animal Models |
| title_fullStr |
Ocular Manifestations of Alzheimer's Disease in Animal Models |
| title_full_unstemmed |
Ocular Manifestations of Alzheimer's Disease in Animal Models |
| title_sort |
ocular manifestations of alzheimer's disease in animal models |
| description |
Alzheimer's disease (AD) is the most common form of dementia, and the pathological changes of senile plaques (SPs) and neurofibrillary tangles (NFTs) in AD brains are well described. Clinically, a diagnosis remains a postmortem one, hampering both accurate and early diagnosis as well as research into potential new treatments. Visual deficits have long been noted in AD patients, and it is becoming increasingly apparent that histopathological changes already noted in the brain also occur in an extension of the brain; the retina. Due to the optically transparent nature of the eye, it is possible to image the retina at a cellular level noninvasively and thus potentially allow an earlier diagnosis as well as a way of monitoring progression and treatment effects. Transgenic animal models expressing amyloid precursor protein (APP) presenilin (PS) and tau mutations have been used successfully to recapitulate the pathological findings of AD in the brain. This paper will cover the ocular abnormalities that have been detected in these transgenic AD animal models. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362039/ |
| _version_ |
1611532977243684864 |