LDL-Apheresis: Technical and Clinical Aspects

The prognosis of patients suffering from severe hyperlipidemia, sometimes combined with elevated lipoprotein (a) levels, and coronary heart disease refractory to diet and lipid-lowering drugs is poor. For such patients, regular treatment with low-density lipoprotein (LDL) apheresis is the therapeuti...

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Main Authors:	Bambauer, Rolf, Bambauer, Carolin, Lehmann, Boris, Latza, Reinhard, Schiel, Ralf
Format:	Online
Language:	English
Published:	The Scientific World Journal 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361163/

id	pubmed-3361163
recordtype	oai_dc
spelling	pubmed-33611632012-05-31 LDL-Apheresis: Technical and Clinical Aspects Bambauer, Rolf Bambauer, Carolin Lehmann, Boris Latza, Reinhard Schiel, Ralf Review Article The prognosis of patients suffering from severe hyperlipidemia, sometimes combined with elevated lipoprotein (a) levels, and coronary heart disease refractory to diet and lipid-lowering drugs is poor. For such patients, regular treatment with low-density lipoprotein (LDL) apheresis is the therapeutic option. Today, there are five different LDL-apheresis systems available: cascade filtration or lipid filtration, immunoadsorption, heparin-induced LDL precipitation, dextran sulfate LDL adsorption, and the LDL hemoperfusion. There is a strong correlation between hyperlipidemia and atherosclerosis. Besides the elimination of other risk factors, in severe hyperlipidemia therapeutic strategies should focus on a drastic reduction of serum lipoproteins. Despite maximum conventional therapy with a combination of different kinds of lipid-lowering drugs, sometimes the goal of therapy cannot be reached. Hence, in such patients, treatment with LDL-apheresis is indicated. Technical and clinical aspects of these five different LDL-apheresis methods are shown here. There were no significant differences with respect to or concerning all cholesterols, or triglycerides observed. With respect to elevated lipoprotein (a) levels, however, the immunoadsorption method seems to be most effective. The different published data clearly demonstrate that treatment with LDL-apheresis in patients suffering from severe hyperlipidemia refractory to maximum conservative therapy is effective and safe in long-term application. The Scientific World Journal 2012-04-30 /pmc/articles/PMC3361163/ /pubmed/22654591 http://dx.doi.org/10.1100/2012/314283 Text en Copyright © 2012 Rolf Bambauer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bambauer, Rolf Bambauer, Carolin Lehmann, Boris Latza, Reinhard Schiel, Ralf
spellingShingle	Bambauer, Rolf Bambauer, Carolin Lehmann, Boris Latza, Reinhard Schiel, Ralf LDL-Apheresis: Technical and Clinical Aspects
author_facet	Bambauer, Rolf Bambauer, Carolin Lehmann, Boris Latza, Reinhard Schiel, Ralf
author_sort	Bambauer, Rolf
title	LDL-Apheresis: Technical and Clinical Aspects
title_short	LDL-Apheresis: Technical and Clinical Aspects
title_full	LDL-Apheresis: Technical and Clinical Aspects
title_fullStr	LDL-Apheresis: Technical and Clinical Aspects
title_full_unstemmed	LDL-Apheresis: Technical and Clinical Aspects
title_sort	ldl-apheresis: technical and clinical aspects
description	The prognosis of patients suffering from severe hyperlipidemia, sometimes combined with elevated lipoprotein (a) levels, and coronary heart disease refractory to diet and lipid-lowering drugs is poor. For such patients, regular treatment with low-density lipoprotein (LDL) apheresis is the therapeutic option. Today, there are five different LDL-apheresis systems available: cascade filtration or lipid filtration, immunoadsorption, heparin-induced LDL precipitation, dextran sulfate LDL adsorption, and the LDL hemoperfusion. There is a strong correlation between hyperlipidemia and atherosclerosis. Besides the elimination of other risk factors, in severe hyperlipidemia therapeutic strategies should focus on a drastic reduction of serum lipoproteins. Despite maximum conventional therapy with a combination of different kinds of lipid-lowering drugs, sometimes the goal of therapy cannot be reached. Hence, in such patients, treatment with LDL-apheresis is indicated. Technical and clinical aspects of these five different LDL-apheresis methods are shown here. There were no significant differences with respect to or concerning all cholesterols, or triglycerides observed. With respect to elevated lipoprotein (a) levels, however, the immunoadsorption method seems to be most effective. The different published data clearly demonstrate that treatment with LDL-apheresis in patients suffering from severe hyperlipidemia refractory to maximum conservative therapy is effective and safe in long-term application.
publisher	The Scientific World Journal
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361163/
_version_	1611532715853611008

LDL-Apheresis: Technical and Clinical Aspects

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