Differing Von Hippel Lindau Genotype in Paired Primary and Metastatic Tumors in Patients with Clear Cell Renal Cell Carcinoma

Differing Von Hippel Lindau Genotype in Paired Primary and Metastatic Tumors in Patients with Clear Cell Renal Cell Carcinoma

In sporadic clear cell renal cell carcinoma (CCRCC), the von Hippel Lindau (VHL) gene is inactivated by mutation or methylation in the majority of primary (P) tumors. Due to differing effects of wild-type (WT) and mutant (MT) VHL gene on downstream signaling pathways regulating angiogenesis, VHL gen...

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Bibliographic Details
Main Authors: Vaziri, Susan A. J., Tavares, Emmanuel J., Golshayan, Ali R., Rini, Brian I., Aydin, Hakan, Zhou, Ming, Sercia, Linda, Wood, Laura, Ganapathi, Mahrukh K., Bukowski, Ronald M., Ganapathi, Ram
Format: Online
Language:English
Published: Frontiers Research Foundation 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361062/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361062/

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