Differential Degradation of Full-length and Cleaved Ataxin-7 Fragments in a Novel Stable Inducible SCA7 Model
Spinocerebellar ataxia type 7 (SCA7) is one of nine neurodegenerative disorders caused by expanded polyglutamine repeats, and a common toxic gain-of-function mechanism has been proposed. Proteolytic cleavage of several polyglutamine proteins has been identified and suggested to modulate the polyglut...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Humana Press Inc
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360856/ |