EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

The epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile mesenchymal ones. EMT–inducing transcription factors are aberrantly expressed in multiple tumor types and are known to favor the metastatic dissem...

Full description

Bibliographic Details
Main Authors: Morel, Anne-Pierre, Hinkal, George W., Thomas, Clémence, Fauvet, Frédérique, Courtois-Cox, Stéphanie, Wierinckx, Anne, Devouassoux-Shisheboran, Mojgan, Treilleux, Isabelle, Tissier, Agnès, Gras, Baptiste, Pourchet, Julie, Puisieux, Isabelle, Browne, Gareth J., Spicer, Douglas B., Lachuer, Joël, Ansieau, Stéphane, Puisieux, Alain
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359981/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359981/

Similar Items