Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice
The cholinergic theory of depression highlights the involvement of muscarinic acetylcholine receptors in the neurobiology of mood disorders. The present study was designed to investigate the effect of sildenafil, a phosphodiesterase type 5 inhibitor which exhibits cholinomimetic properties, alone an...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer Vienna
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359440/ |