Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators with improved clinical profiles are needed. We obtained a crystal structure of...

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Bibliographic Details
Main Authors: Liberato, Marcelo Vizoná, Nascimento, Alessandro S., Ayers, Steven D., Lin, Jean Z., Cvoro, Aleksandra, Silveira, Rodrigo L., Martínez, Leandro, Souza, Paulo C. T., Saidemberg, Daniel, Deng, Tuo, Amato, Angela Angelica, Togashi, Marie, Hsueh, Willa A., Phillips, Kevin, Palma, Mário Sérgio, Neves, Francisco A. R., Skaf, Munir S., Webb, Paul, Polikarpov, Igor
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359336/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359336/

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