Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid
Thymidylate synthase (TS) enzymes catalyse the biosynthesis of deoxythymidine monophosphate (dTMP or thymidylate), and so are important for DNA replication and repair. Two different types of TS proteins have been described (ThyA and ThyX), which have different enzymic mechanisms and unrelated struct...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Society for General Microbiology
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352284/ |