2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo

2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo

Prior studies have shown that 2′-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. Viruses lacking 2′-O methyltransferase activity exhibited attenuation in primary macrophages that was...

Full description

Bibliographic Details
Main Authors: Szretter, Kristy J., Daniels, Brian P., Cho, Hyelim, Gainey, Maria D., Yokoyama, Wayne M., Gale, Michael, Virgin, Herbert W., Klein, Robyn S., Sen, Ganes C., Diamond, Michael S.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349756/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349756/

Similar Items