Mast Cells Respond to Cell Injury through the Recognition of IL-33
Mast cells have been attributed several functions in both health and disease. Mast cell activation and release of inflammatory mediators are associated with the pathogenesis of several diseases, in particular that of allergic diseases. While the notion of mast cells as important, protective sentinel...
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Frontiers Research Foundation
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342375/ |
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pubmed-3342375 |
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pubmed-33423752012-05-07 Mast Cells Respond to Cell Injury through the Recognition of IL-33 Lunderius-Andersson, Carolina Enoksson, Mattias Nilsson, Gunnar Immunology Mast cells have been attributed several functions in both health and disease. Mast cell activation and release of inflammatory mediators are associated with the pathogenesis of several diseases, in particular that of allergic diseases. While the notion of mast cells as important, protective sentinel cells is old, this feature of the cell is not well recognized outside the mast cell field. The mast cell is a unique, multifunctional cell of our defense system, with characteristics such as wide-spread tissue distribution, expression of receptors capable of recognizing both endogenous and exogenous agents, and a capability to rapidly respond to triggering factors by selective mediator release. In this review, we discuss the function of mast cells as sentinel cells in the context of cell injury, where mast cells respond by initiating an inflammatory response. In this setting, IL-33 has turned out to be of particular interest. IL-33 is released by necrotic structural cells and is recognized by mast cells via the IL-33 receptor ST2. IL-33 and mast cells probably constitute one important link between cell injury and an inflammatory response that can lead to restoration of tissue function and homeostasis, but might under other circumstances contribute to a vicious circle driving chronic inflammation. Frontiers Research Foundation 2012-04-19 /pmc/articles/PMC3342375/ /pubmed/22566963 http://dx.doi.org/10.3389/fimmu.2012.00082 Text en Copyright © 2012 Lunderius-Andersson, Enoksson and Nilsson. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lunderius-Andersson, Carolina Enoksson, Mattias Nilsson, Gunnar |
| spellingShingle |
Lunderius-Andersson, Carolina Enoksson, Mattias Nilsson, Gunnar Mast Cells Respond to Cell Injury through the Recognition of IL-33 |
| author_facet |
Lunderius-Andersson, Carolina Enoksson, Mattias Nilsson, Gunnar |
| author_sort |
Lunderius-Andersson, Carolina |
| title |
Mast Cells Respond to Cell Injury through the Recognition of IL-33 |
| title_short |
Mast Cells Respond to Cell Injury through the Recognition of IL-33 |
| title_full |
Mast Cells Respond to Cell Injury through the Recognition of IL-33 |
| title_fullStr |
Mast Cells Respond to Cell Injury through the Recognition of IL-33 |
| title_full_unstemmed |
Mast Cells Respond to Cell Injury through the Recognition of IL-33 |
| title_sort |
mast cells respond to cell injury through the recognition of il-33 |
| description |
Mast cells have been attributed several functions in both health and disease. Mast cell activation and release of inflammatory mediators are associated with the pathogenesis of several diseases, in particular that of allergic diseases. While the notion of mast cells as important, protective sentinel cells is old, this feature of the cell is not well recognized outside the mast cell field. The mast cell is a unique, multifunctional cell of our defense system, with characteristics such as wide-spread tissue distribution, expression of receptors capable of recognizing both endogenous and exogenous agents, and a capability to rapidly respond to triggering factors by selective mediator release. In this review, we discuss the function of mast cells as sentinel cells in the context of cell injury, where mast cells respond by initiating an inflammatory response. In this setting, IL-33 has turned out to be of particular interest. IL-33 is released by necrotic structural cells and is recognized by mast cells via the IL-33 receptor ST2. IL-33 and mast cells probably constitute one important link between cell injury and an inflammatory response that can lead to restoration of tissue function and homeostasis, but might under other circumstances contribute to a vicious circle driving chronic inflammation. |
| publisher |
Frontiers Research Foundation |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342375/ |
| _version_ |
1611526605405945856 |