The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12
The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53N236S (p53N239S in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of function is...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Ivyspring International Publisher
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341601/ |