The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications
Prostate cancer is a global public health problem, and it is the most common cancer in American men and the second cause for cancer-related death. Experimental evidence shows that prostate tissue possesses cannabinoid receptors and their stimulation results in anti-androgenic effects. To review curr...
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| Format: | Online |
| Language: | English |
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Medknow Publications & Media Pvt Ltd
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/ |
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pubmed-33397952012-05-03 The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications Ramos, Juan A. Bianco, Fernando J. Review Article Prostate cancer is a global public health problem, and it is the most common cancer in American men and the second cause for cancer-related death. Experimental evidence shows that prostate tissue possesses cannabinoid receptors and their stimulation results in anti-androgenic effects. To review currently relevant findings related to effects of cannabinoid receptors in prostate cancer. PubMed search utilizing the terms “cannabis,” “cannabinoids,” “prostate cancer,” and “cancer pain management,” giving preference to most recent publications was done. Articles identified were screened for their relevance to the field of prostate cancer and interest to both urologist and pain specialists. Prostate cancer cells possess increased expression of both cannabinoid 1 and 2 receptors, and stimulation of these results in decrease in cell viability, increased apoptosis, and decreased androgen receptor expression and prostate-specific antigen excretion. It would be of interest to conduct clinical studies utilizing cannabinoids for patients with metastatic prostate cancer, taking advantage not only of its beneficial effects on prostate cancer but also of their analgesic properties for bone metastatic cancer pain. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3339795/ /pubmed/22557710 http://dx.doi.org/10.4103/0970-1591.94942 Text en Copyright: © Indian Journal of Urology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Ramos, Juan A. Bianco, Fernando J. |
| spellingShingle |
Ramos, Juan A. Bianco, Fernando J. The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| author_facet |
Ramos, Juan A. Bianco, Fernando J. |
| author_sort |
Ramos, Juan A. |
| title |
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_short |
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_full |
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_fullStr |
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_full_unstemmed |
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_sort |
role of cannabinoids in prostate cancer: basic science perspective and potential clinical applications |
| description |
Prostate cancer is a global public health problem, and it is the most common cancer in American men and the second cause for cancer-related death. Experimental evidence shows that prostate tissue possesses cannabinoid receptors and their stimulation results in anti-androgenic effects. To review currently relevant findings related to effects of cannabinoid receptors in prostate cancer. PubMed search utilizing the terms “cannabis,” “cannabinoids,” “prostate cancer,” and “cancer pain management,” giving preference to most recent publications was done. Articles identified were screened for their relevance to the field of prostate cancer and interest to both urologist and pain specialists. Prostate cancer cells possess increased expression of both cannabinoid 1 and 2 receptors, and stimulation of these results in decrease in cell viability, increased apoptosis, and decreased androgen receptor expression and prostate-specific antigen excretion. It would be of interest to conduct clinical studies utilizing cannabinoids for patients with metastatic prostate cancer, taking advantage not only of its beneficial effects on prostate cancer but also of their analgesic properties for bone metastatic cancer pain. |
| publisher |
Medknow Publications & Media Pvt Ltd |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/ |
| _version_ |
1611525914737246208 |