Standard Error of Empirical Bayes Estimate in NONMEM® VI

The pharmacokinetics/pharmacodynamics analysis software NONMEM® output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple and direct method for estimating standard error o...

Full description

Bibliographic Details
Main Authors: Kang, Dongwoo, Bae, Kyun-Seop, Houk, Brett E., Savic, Radojka M., Karlsson, Mats O.
Format: Online
Language:English
Published: The Korean Physiological Society and The Korean Society of Pharmacology 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339294/