Partial tandem duplication of mtDNA–tRNAPhe impairs mtDNA translation in late-onset mitochondrial myopathy
An 80-year-old woman (PI) has been suffering of late onset progressive weakness and wasting of lower-limb muscles, accompanied by high creatine kinase levels in blood. A muscle biopsy, performed at 63 years, showed myopathic features with partial deficiency of cytochrome c oxidase. A second biopsy t...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Pergamon Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334271/ |