Primary Transgenic Bovine Cells and Their Rejuvenated Cloned Equivalents Show Transgene-Specific Epigenetic Differences

Primary Transgenic Bovine Cells and Their Rejuvenated Cloned Equivalents Show Transgene-Specific Epigenetic Differences

Cell-mediated transgenesis, based on somatic cell nuclear transfer (SCNT), provides the opportunity to shape the genetic make-up of cattle. Bovine primary fetal fibroblasts, commonly used cells for SCNT, have a limited lifespan, and complex genetic modifications that require sequential transfections...

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Bibliographic Details
Main Authors: Alonso-González, Lucia, Couldrey, Christine, Meinhardt, Marcus W., Cole, Sally A., Wells, David N., Laible, Götz
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332029/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332029/

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