Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy
The Raf-MEK-ERK pathway is commonly activated in human cancers, largely attributable to the extracellular signal-regulated kinases (ERKs) being a common downstream target of growth factor receptors, Ras, and Raf. Elevation of these up-stream signals occurs frequently in a variety of malignancies and...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Bentham Science Publishers
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330700/ |