Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis

The treatment strategy for cases of combined autoimmune hepatitis (AIH) and chronic hepatitis C (CHC) has not yet been established. A 47-year-old woman and a 53-year-old-woman were hospitalized for treatment of CHC. Ultrasonography and histological findings revealed that their liver was not cirrhoti...

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Main Authors:	Oeda, Satoshi, Mizuta, Toshihiko, Isoda, Hiroshi, Kuwashiro, Takuya, Oza, Noriko, Iwane, Shinji, Takahashi, Hirokazu, Kawaguchi, Yasunori, Eguchi, Yuichiro, Toda, Shuji, Ozaki, Iwata, Anzai, Keizo, Fujimoto, Kazuma
Format:	Online
Language:	English
Published:	Springer Japan 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328672/

id	pubmed-3328672
recordtype	oai_dc
spelling	pubmed-33286722012-05-14 Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis Oeda, Satoshi Mizuta, Toshihiko Isoda, Hiroshi Kuwashiro, Takuya Oza, Noriko Iwane, Shinji Takahashi, Hirokazu Kawaguchi, Yasunori Eguchi, Yuichiro Toda, Shuji Ozaki, Iwata Anzai, Keizo Fujimoto, Kazuma Case Report The treatment strategy for cases of combined autoimmune hepatitis (AIH) and chronic hepatitis C (CHC) has not yet been established. A 47-year-old woman and a 53-year-old-woman were hospitalized for treatment of CHC. Ultrasonography and histological findings revealed that their liver was not cirrhotic but did have chronic damage. The histological findings of both patients were suggestive of AIH. The patients were systematically treated with pegylated interferon-alpha 2b plus ribavirin which was preceded by and combined with corticosteroid (CS), and showed sustained virological responses and normal liver function. Although these two patients with combined AIH and CHC were successfully treated with this regimen, careful attention to exacerbation of hepatic inflammation is needed because hepatitis C viral load was increased due to immunosuppression during CS treatment. Springer Japan 2012-03-28 2012-04 /pmc/articles/PMC3328672/ /pubmed/22593772 http://dx.doi.org/10.1007/s12328-012-0295-4 Text en © The Author(s) 2012
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Oeda, Satoshi Mizuta, Toshihiko Isoda, Hiroshi Kuwashiro, Takuya Oza, Noriko Iwane, Shinji Takahashi, Hirokazu Kawaguchi, Yasunori Eguchi, Yuichiro Toda, Shuji Ozaki, Iwata Anzai, Keizo Fujimoto, Kazuma
spellingShingle	Oeda, Satoshi Mizuta, Toshihiko Isoda, Hiroshi Kuwashiro, Takuya Oza, Noriko Iwane, Shinji Takahashi, Hirokazu Kawaguchi, Yasunori Eguchi, Yuichiro Toda, Shuji Ozaki, Iwata Anzai, Keizo Fujimoto, Kazuma Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis
author_facet	Oeda, Satoshi Mizuta, Toshihiko Isoda, Hiroshi Kuwashiro, Takuya Oza, Noriko Iwane, Shinji Takahashi, Hirokazu Kawaguchi, Yasunori Eguchi, Yuichiro Toda, Shuji Ozaki, Iwata Anzai, Keizo Fujimoto, Kazuma
author_sort	Oeda, Satoshi
title	Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis
title_short	Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis
title_full	Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis
title_fullStr	Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis
title_full_unstemmed	Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis
title_sort	efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis c and autoimmune hepatitis
description	The treatment strategy for cases of combined autoimmune hepatitis (AIH) and chronic hepatitis C (CHC) has not yet been established. A 47-year-old woman and a 53-year-old-woman were hospitalized for treatment of CHC. Ultrasonography and histological findings revealed that their liver was not cirrhotic but did have chronic damage. The histological findings of both patients were suggestive of AIH. The patients were systematically treated with pegylated interferon-alpha 2b plus ribavirin which was preceded by and combined with corticosteroid (CS), and showed sustained virological responses and normal liver function. Although these two patients with combined AIH and CHC were successfully treated with this regimen, careful attention to exacerbation of hepatic inflammation is needed because hepatitis C viral load was increased due to immunosuppression during CS treatment.
publisher	Springer Japan
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328672/
_version_	1611521607334887424

Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis

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