Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets
Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in cancer,...
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| Format: | Online |
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Public Library of Science
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325923/ |
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pubmed-3325923 |
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pubmed-33259232012-04-18 Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets Macia, Laurence Tsai, Vicky Wang-Wei Nguyen, Amy D. Johnen, Heiko Kuffner, Tamara Shi, Yan-Chuan Lin, Shu Herzog, Herbert Brown, David A. Breit, Samuel N. Sainsbury, Amanda Research Article Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in cancer, provides protection against the development of obesity. Both under a normal chow diet and an obesogenic diet, the transgenic overexpression of MIC-1/GDF15 in mice leads to decreased body weight and fat mass. This lean phenotype was associated with decreased spontaneous but not fasting-induced food intake, on a background of unaltered energy expenditure and reduced physical activity. Importantly, the overexpression of MIC-1/GDF15 improved glucose tolerance, both under normal and high fat-fed conditions. Altogether, this work shows that the molecule MIC-1/GDF15 might be beneficial for the treatment of obesity as well as perturbations in glucose homeostasis. Public Library of Science 2012-04-13 /pmc/articles/PMC3325923/ /pubmed/22514681 http://dx.doi.org/10.1371/journal.pone.0034868 Text en Macia et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Macia, Laurence Tsai, Vicky Wang-Wei Nguyen, Amy D. Johnen, Heiko Kuffner, Tamara Shi, Yan-Chuan Lin, Shu Herzog, Herbert Brown, David A. Breit, Samuel N. Sainsbury, Amanda |
| spellingShingle |
Macia, Laurence Tsai, Vicky Wang-Wei Nguyen, Amy D. Johnen, Heiko Kuffner, Tamara Shi, Yan-Chuan Lin, Shu Herzog, Herbert Brown, David A. Breit, Samuel N. Sainsbury, Amanda Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets |
| author_facet |
Macia, Laurence Tsai, Vicky Wang-Wei Nguyen, Amy D. Johnen, Heiko Kuffner, Tamara Shi, Yan-Chuan Lin, Shu Herzog, Herbert Brown, David A. Breit, Samuel N. Sainsbury, Amanda |
| author_sort |
Macia, Laurence |
| title |
Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets |
| title_short |
Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets |
| title_full |
Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets |
| title_fullStr |
Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets |
| title_full_unstemmed |
Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets |
| title_sort |
macrophage inhibitory cytokine 1 (mic-1/gdf15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets |
| description |
Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in cancer, provides protection against the development of obesity. Both under a normal chow diet and an obesogenic diet, the transgenic overexpression of MIC-1/GDF15 in mice leads to decreased body weight and fat mass. This lean phenotype was associated with decreased spontaneous but not fasting-induced food intake, on a background of unaltered energy expenditure and reduced physical activity. Importantly, the overexpression of MIC-1/GDF15 improved glucose tolerance, both under normal and high fat-fed conditions. Altogether, this work shows that the molecule MIC-1/GDF15 might be beneficial for the treatment of obesity as well as perturbations in glucose homeostasis. |
| publisher |
Public Library of Science |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325923/ |
| _version_ |
1611520851673350144 |