Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

The majority of broadly neutralizing antibodies to hepatitis C virus (HCV) are against conformational epitopes on the E2 glycoprotein. Many of them recognize overlapping epitopes in a cluster, designated as antigenic domain B, that contains residues G530 and D535. To gain information on other region...

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Bibliographic Details
Main Authors: Keck, Zhen-yong, Xia, Jinming, Wang, Yong, Wang, Wenyan, Krey, Thomas, Prentoe, Jannick, Carlsen, Thomas, Li, Angela Ying-Jian, Patel, Arvind H., Lemon, Stanley M., Bukh, Jens, Rey, Felix A., Foung, Steven K. H.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325216/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325216/

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