Antigenic and Genetic Variability of Human Metapneumoviruses

Human metapneumovirus (HMPV) is a member of the subfamily Pneumovirinae within the family Paramyxoviridae. Other members of this subfamily, respiratory syncytial virus and avian pneumovirus, can be divided into subgroups based on genetic or antigenic differences or both. For HMPV, the existence of d...

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Main Authors:	van den Hoogen, Bernadette G., Herfst, Sander, Sprong, Leo, Cane, Patricia A., Forleo-Neto, Eduardo, de Swart, Rik L., Osterhaus, Albert D.M.E., Fouchier, Ron A.M.
Format:	Online
Language:	English
Published:	Centers for Disease Control and Prevention 2004
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323073/

id	pubmed-3323073
recordtype	oai_dc
spelling	pubmed-33230732012-04-17 Antigenic and Genetic Variability of Human Metapneumoviruses van den Hoogen, Bernadette G. Herfst, Sander Sprong, Leo Cane, Patricia A. Forleo-Neto, Eduardo de Swart, Rik L. Osterhaus, Albert D.M.E. Fouchier, Ron A.M. Research Human metapneumovirus (HMPV) is a member of the subfamily Pneumovirinae within the family Paramyxoviridae. Other members of this subfamily, respiratory syncytial virus and avian pneumovirus, can be divided into subgroups based on genetic or antigenic differences or both. For HMPV, the existence of different genetic lineages has been described on the basis of variation in a limited set of available sequences. We address the antigenic relationship between genetic lineages in virus neutralization assays. In addition, we analyzed the genetic diversity of HMPV by phylogenetic analysis of sequences obtained for part of the fusion protein (n = 84) and the complete attachment protein open reading frames (n = 35). On the basis of sequence diversity between attachment protein genes and the differences in virus neutralization titers, two HMPV serotypes were defined. Each serotype could be divided into two genetic lineages, but these did not reflect major antigenic differences. Centers for Disease Control and Prevention 2004-04 /pmc/articles/PMC3323073/ /pubmed/15200856 http://dx.doi.org/10.3201/eid1004.030393 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	van den Hoogen, Bernadette G. Herfst, Sander Sprong, Leo Cane, Patricia A. Forleo-Neto, Eduardo de Swart, Rik L. Osterhaus, Albert D.M.E. Fouchier, Ron A.M.
spellingShingle	van den Hoogen, Bernadette G. Herfst, Sander Sprong, Leo Cane, Patricia A. Forleo-Neto, Eduardo de Swart, Rik L. Osterhaus, Albert D.M.E. Fouchier, Ron A.M. Antigenic and Genetic Variability of Human Metapneumoviruses
author_facet	van den Hoogen, Bernadette G. Herfst, Sander Sprong, Leo Cane, Patricia A. Forleo-Neto, Eduardo de Swart, Rik L. Osterhaus, Albert D.M.E. Fouchier, Ron A.M.
author_sort	van den Hoogen, Bernadette G.
title	Antigenic and Genetic Variability of Human Metapneumoviruses
title_short	Antigenic and Genetic Variability of Human Metapneumoviruses
title_full	Antigenic and Genetic Variability of Human Metapneumoviruses
title_fullStr	Antigenic and Genetic Variability of Human Metapneumoviruses
title_full_unstemmed	Antigenic and Genetic Variability of Human Metapneumoviruses
title_sort	antigenic and genetic variability of human metapneumoviruses
description	Human metapneumovirus (HMPV) is a member of the subfamily Pneumovirinae within the family Paramyxoviridae. Other members of this subfamily, respiratory syncytial virus and avian pneumovirus, can be divided into subgroups based on genetic or antigenic differences or both. For HMPV, the existence of different genetic lineages has been described on the basis of variation in a limited set of available sequences. We address the antigenic relationship between genetic lineages in virus neutralization assays. In addition, we analyzed the genetic diversity of HMPV by phylogenetic analysis of sequences obtained for part of the fusion protein (n = 84) and the complete attachment protein open reading frames (n = 35). On the basis of sequence diversity between attachment protein genes and the differences in virus neutralization titers, two HMPV serotypes were defined. Each serotype could be divided into two genetic lineages, but these did not reflect major antigenic differences.
publisher	Centers for Disease Control and Prevention
publishDate	2004
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323073/
_version_	1611519973702762496

Antigenic and Genetic Variability of Human Metapneumoviruses

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