The genomic basis of adaptive evolution in threespine sticklebacks
Marine stickleback fish have colonized and adapted to innumerable streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. Here we develop a high quality reference genome assembly for...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322419/ |
| id |
pubmed-3322419 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-33224192012-10-05 The genomic basis of adaptive evolution in threespine sticklebacks Jones, Felicity C Grabherr, Manfred G Chan, Yingguang Frank Russell, Pamela Mauceli, Evan Johnson, Jeremy Swofford, Ross Pirun, Mono Zody, Michael C White, Simon Birney, Ewan Searle, Stephen Schmutz, Jeremy Grimwood, Jane Dickson, Mark C Myers, Richard M Miller, Craig T Summers, Brian R Knecht, Anne K Brady, Shannon D Zhang, Haili Pollen, Alex A Howes, Timothy Amemiya, Chris Lander, Eric S Di Palma, Federica Lindblad-Toh, Kerstin Kingsley, David M Article Marine stickleback fish have colonized and adapted to innumerable streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. Here we develop a high quality reference genome assembly for threespine sticklebacks. By sequencing the genomes of 20 additional individuals from a global set of marine and freshwater populations, we identify a genome-wide set of loci that are consistently associated with marine-freshwater divergence. Our results suggest that reuse of globally-shared standing genetic variation, including chromosomal inversions, plays an important role in repeated evolution of distinct marine and freshwater sticklebacks, and in the maintenance of divergent ecotypes during early stages of reproductive isolation. Both coding and regulatory changes occur in the set of loci underlying marine-freshwater evolution, with regulatory changes likely predominating in this classic example of repeated adaptive evolution in nature. 2012-04-04 /pmc/articles/PMC3322419/ /pubmed/22481358 http://dx.doi.org/10.1038/nature10944 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jones, Felicity C Grabherr, Manfred G Chan, Yingguang Frank Russell, Pamela Mauceli, Evan Johnson, Jeremy Swofford, Ross Pirun, Mono Zody, Michael C White, Simon Birney, Ewan Searle, Stephen Schmutz, Jeremy Grimwood, Jane Dickson, Mark C Myers, Richard M Miller, Craig T Summers, Brian R Knecht, Anne K Brady, Shannon D Zhang, Haili Pollen, Alex A Howes, Timothy Amemiya, Chris Lander, Eric S Di Palma, Federica Lindblad-Toh, Kerstin Kingsley, David M |
| spellingShingle |
Jones, Felicity C Grabherr, Manfred G Chan, Yingguang Frank Russell, Pamela Mauceli, Evan Johnson, Jeremy Swofford, Ross Pirun, Mono Zody, Michael C White, Simon Birney, Ewan Searle, Stephen Schmutz, Jeremy Grimwood, Jane Dickson, Mark C Myers, Richard M Miller, Craig T Summers, Brian R Knecht, Anne K Brady, Shannon D Zhang, Haili Pollen, Alex A Howes, Timothy Amemiya, Chris Lander, Eric S Di Palma, Federica Lindblad-Toh, Kerstin Kingsley, David M The genomic basis of adaptive evolution in threespine sticklebacks |
| author_facet |
Jones, Felicity C Grabherr, Manfred G Chan, Yingguang Frank Russell, Pamela Mauceli, Evan Johnson, Jeremy Swofford, Ross Pirun, Mono Zody, Michael C White, Simon Birney, Ewan Searle, Stephen Schmutz, Jeremy Grimwood, Jane Dickson, Mark C Myers, Richard M Miller, Craig T Summers, Brian R Knecht, Anne K Brady, Shannon D Zhang, Haili Pollen, Alex A Howes, Timothy Amemiya, Chris Lander, Eric S Di Palma, Federica Lindblad-Toh, Kerstin Kingsley, David M |
| author_sort |
Jones, Felicity C |
| title |
The genomic basis of adaptive evolution in threespine sticklebacks |
| title_short |
The genomic basis of adaptive evolution in threespine sticklebacks |
| title_full |
The genomic basis of adaptive evolution in threespine sticklebacks |
| title_fullStr |
The genomic basis of adaptive evolution in threespine sticklebacks |
| title_full_unstemmed |
The genomic basis of adaptive evolution in threespine sticklebacks |
| title_sort |
genomic basis of adaptive evolution in threespine sticklebacks |
| description |
Marine stickleback fish have colonized and adapted to innumerable streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. Here we develop a high quality reference genome assembly for threespine sticklebacks. By sequencing the genomes of 20 additional individuals from a global set of marine and freshwater populations, we identify a genome-wide set of loci that are consistently associated with marine-freshwater divergence. Our results suggest that reuse of globally-shared standing genetic variation, including chromosomal inversions, plays an important role in repeated evolution of distinct marine and freshwater sticklebacks, and in the maintenance of divergent ecotypes during early stages of reproductive isolation. Both coding and regulatory changes occur in the set of loci underlying marine-freshwater evolution, with regulatory changes likely predominating in this classic example of repeated adaptive evolution in nature. |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322419/ |
| _version_ |
1611519792215228416 |