A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

Crystallographic structures encompassing GPCR autoproteolytic sequences (GPS) delineate a novel conserved structural domain called GAIN, which is found in cell-adhesion GPCRs, polycystic kidney disease proteins conserved throughout evolution.

Bibliographic Details
Main Authors: Araç, Demet, Boucard, Antony A, Bolliger, Marc F, Nguyen, Jenna, Soltis, S Michael, Südhof, Thomas C, Brunger, Axel T
Format: Online
Language:English
Published: Nature Publishing Group 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321182/