Isoflavones-Enriched Soy Protein Prevents CCL4-Induced Hepatotoxicity in Rats

The burden of liver disease in Egypt is exceptionally high due to the highest prevalence of hepatitis C virus (HCV) resulting in rising rates of hepatocellular carcinoma (HCC). The aim of the current study was to determine the isoflavones in soy and to evaluate the protective role of soy against CCl...

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Main Authors:	Sarhan, Nesma A. Z., El-Denshary, Ezzeldein S., Hassan, Nabila S., Abu-Salem, Ferial M., Abdel-Wahhab, Mosaad A.
Format:	Online
Language:	English
Published:	International Scholarly Research Network 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317079/

id	pubmed-3317079
recordtype	oai_dc
spelling	pubmed-33170792012-04-23 Isoflavones-Enriched Soy Protein Prevents CCL4-Induced Hepatotoxicity in Rats Sarhan, Nesma A. Z. El-Denshary, Ezzeldein S. Hassan, Nabila S. Abu-Salem, Ferial M. Abdel-Wahhab, Mosaad A. Research Article The burden of liver disease in Egypt is exceptionally high due to the highest prevalence of hepatitis C virus (HCV) resulting in rising rates of hepatocellular carcinoma (HCC). The aim of the current study was to determine the isoflavones in soy and to evaluate the protective role of soy against CCl4-induced liver damage in rats. Four experimental groups were treated for 8 weeks and included the control group, soy-supplemented diet (20% w/w) group, the group treated orally with CCl4 (100 mg/kg bw) twice a week, and the group fed soy-supplemented diet and treated with CCl4. Blood and liver tissue samples were collected for biochemical analyses and histological examination. The results indicated that protein content was 45.8% and the total isoflavones recorded 167.3 mg/100 g soy. Treatment with CCl4 resulted in a significant biochemical changes in serum liver tissue accompanied with severe oxidative stress and histological changes. Supplementation with soy succeeded to restore the elevation of liver enzymes activities and improved serum biochemical parameters. Moreover, soy supplementation improved the antioxidant enzymes, decreased lipid peroxidation, and improved the histological picture of the liver tissue. It could be concluded that soy-protein-enriched isoflavones may be a promising agent against liver diseases. International Scholarly Research Network 2012-03-01 /pmc/articles/PMC3317079/ /pubmed/22530140 http://dx.doi.org/10.5402/2012/347930 Text en Copyright © 2012 Nesma A. Z. Sarhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sarhan, Nesma A. Z. El-Denshary, Ezzeldein S. Hassan, Nabila S. Abu-Salem, Ferial M. Abdel-Wahhab, Mosaad A.
spellingShingle	Sarhan, Nesma A. Z. El-Denshary, Ezzeldein S. Hassan, Nabila S. Abu-Salem, Ferial M. Abdel-Wahhab, Mosaad A. Isoflavones-Enriched Soy Protein Prevents CCL4-Induced Hepatotoxicity in Rats
author_facet	Sarhan, Nesma A. Z. El-Denshary, Ezzeldein S. Hassan, Nabila S. Abu-Salem, Ferial M. Abdel-Wahhab, Mosaad A.
author_sort	Sarhan, Nesma A. Z.
title	Isoflavones-Enriched Soy Protein Prevents CCL4-Induced Hepatotoxicity in Rats
title_short	Isoflavones-Enriched Soy Protein Prevents CCL4-Induced Hepatotoxicity in Rats
title_full	Isoflavones-Enriched Soy Protein Prevents CCL4-Induced Hepatotoxicity in Rats
title_fullStr	Isoflavones-Enriched Soy Protein Prevents CCL4-Induced Hepatotoxicity in Rats
title_full_unstemmed	Isoflavones-Enriched Soy Protein Prevents CCL4-Induced Hepatotoxicity in Rats
title_sort	isoflavones-enriched soy protein prevents ccl4-induced hepatotoxicity in rats
description	The burden of liver disease in Egypt is exceptionally high due to the highest prevalence of hepatitis C virus (HCV) resulting in rising rates of hepatocellular carcinoma (HCC). The aim of the current study was to determine the isoflavones in soy and to evaluate the protective role of soy against CCl4-induced liver damage in rats. Four experimental groups were treated for 8 weeks and included the control group, soy-supplemented diet (20% w/w) group, the group treated orally with CCl4 (100 mg/kg bw) twice a week, and the group fed soy-supplemented diet and treated with CCl4. Blood and liver tissue samples were collected for biochemical analyses and histological examination. The results indicated that protein content was 45.8% and the total isoflavones recorded 167.3 mg/100 g soy. Treatment with CCl4 resulted in a significant biochemical changes in serum liver tissue accompanied with severe oxidative stress and histological changes. Supplementation with soy succeeded to restore the elevation of liver enzymes activities and improved serum biochemical parameters. Moreover, soy supplementation improved the antioxidant enzymes, decreased lipid peroxidation, and improved the histological picture of the liver tissue. It could be concluded that soy-protein-enriched isoflavones may be a promising agent against liver diseases.
publisher	International Scholarly Research Network
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317079/
_version_	1611518371263676416

Isoflavones-Enriched Soy Protein Prevents CCL4-Induced Hepatotoxicity in Rats

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