Microscale oxygraphy reveals OXPHOS impairment in MRC mutant cells

Given the complexity of the respiratory chain structure, assembly and regulation, the diagnostic workout for the identification of defects of oxidative phosphorylation (OXPHOS) is a major challenge. Spectrophotometric assays, that measure the activity of individual respiratory complexes in tissue an...

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Bibliographic Details
Main Authors: Invernizzi, F., D'Amato, I., Jensen, P.B., Ravaglia, S., Zeviani, M., Tiranti, V.
Format: Online
Language:English
Published: Elsevier Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314980/