Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease

Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease

In conformational diseases, native protein conformers convert to pathological intermediates that polymerize. Structural characterization of these key intermediates is challenging. They are unstable and minimally populated in dynamic equilibria that may be perturbed by many analytical techniques. We...

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Bibliographic Details
Main Authors: Nyon, Mun Peak, Segu, Lakshmi, Cabrita, Lisa D., Lévy, Géraldine R., Kirkpatrick, John, Roussel, Benoit D., Patschull, Anathe O.M., Barrett, Tracey E., Ekeowa, Ugo I., Kerr, Richard, Waudby, Christopher A., Kalsheker, Noor, Hill, Marian, Thalassinos, Konstantinos, Lomas, David A., Christodoulou, John, Gooptu, Bibek
Format: Online
Language:English
Published: Cell Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314904/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314904/

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