Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children

Neurologic complications of children with influenza A H1N1 2009 pandemic, diagnosed in two consecutive influenza seasons were retrospectively reviewed to seek better outcomes in future outbreaks. Patient demographics, clinical manifestations and neurologic outcomes were reviewed. A total of 1,389 ch...

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Main Authors:	Kwon, Soonhak, Kim, Saeyoon, Cho, Min-hyun, Seo, Hyeeun
Format:	Online
Language:	English
Published:	The Korean Academy of Medical Sciences 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314853/

id	pubmed-3314853
recordtype	oai_dc
spelling	pubmed-33148532012-04-01 Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children Kwon, Soonhak Kim, Saeyoon Cho, Min-hyun Seo, Hyeeun Original Article Neurologic complications of children with influenza A H1N1 2009 pandemic, diagnosed in two consecutive influenza seasons were retrospectively reviewed to seek better outcomes in future outbreaks. Patient demographics, clinical manifestations and neurologic outcomes were reviewed. A total of 1,389 children were diagnosed with influenza A H1N1 by real-time reverse transcriptase-polymerase chain reaction. Of these, 23 (1.7%) patients had neurologic involvement. Their mean age was 5.9 ± 3.6 yr (range, 6 months to 11 yr) and 16 (69.9%) were boys. None of the 23 patients had been vaccinated for influenza A H1N1 and seasonal influenzas. Twenty-two of the 23 patients presented with seizures. Clinical features included febrile convulsion (n = 19), afebrile convulsion (n = 1), aseptic meningitis (n = 1), encephalopathy (n = 1), and acute necrotizing encephalopathy (n = 1). They all were treated with Oseltamivir twice daily for 5 days immediately after nasal and throat swab testing. Twenty-one of the subjects recovered fully, but the youngest two infants experienced severe neurological sequelae. The results indicate that neurologic complications associated with influenza A H1N1 2009 pandemic were mostly mild, but rarely were serious. Prompt intervention leads to a better outcome and vaccination may prevent the disease, thus staving off serious neurological complications following influenza, especially in young infants. The Korean Academy of Medical Sciences 2012-04 2012-03-21 /pmc/articles/PMC3314853/ /pubmed/22468104 http://dx.doi.org/10.3346/jkms.2012.27.4.402 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kwon, Soonhak Kim, Saeyoon Cho, Min-hyun Seo, Hyeeun
spellingShingle	Kwon, Soonhak Kim, Saeyoon Cho, Min-hyun Seo, Hyeeun Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children
author_facet	Kwon, Soonhak Kim, Saeyoon Cho, Min-hyun Seo, Hyeeun
author_sort	Kwon, Soonhak
title	Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children
title_short	Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children
title_full	Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children
title_fullStr	Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children
title_full_unstemmed	Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children
title_sort	neurologic complications and outcomes of pandemic (h1n1) 2009 in korean children
description	Neurologic complications of children with influenza A H1N1 2009 pandemic, diagnosed in two consecutive influenza seasons were retrospectively reviewed to seek better outcomes in future outbreaks. Patient demographics, clinical manifestations and neurologic outcomes were reviewed. A total of 1,389 children were diagnosed with influenza A H1N1 by real-time reverse transcriptase-polymerase chain reaction. Of these, 23 (1.7%) patients had neurologic involvement. Their mean age was 5.9 ± 3.6 yr (range, 6 months to 11 yr) and 16 (69.9%) were boys. None of the 23 patients had been vaccinated for influenza A H1N1 and seasonal influenzas. Twenty-two of the 23 patients presented with seizures. Clinical features included febrile convulsion (n = 19), afebrile convulsion (n = 1), aseptic meningitis (n = 1), encephalopathy (n = 1), and acute necrotizing encephalopathy (n = 1). They all were treated with Oseltamivir twice daily for 5 days immediately after nasal and throat swab testing. Twenty-one of the subjects recovered fully, but the youngest two infants experienced severe neurological sequelae. The results indicate that neurologic complications associated with influenza A H1N1 2009 pandemic were mostly mild, but rarely were serious. Prompt intervention leads to a better outcome and vaccination may prevent the disease, thus staving off serious neurological complications following influenza, especially in young infants.
publisher	The Korean Academy of Medical Sciences
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314853/
_version_	1611517460688666624

Neurologic Complications and Outcomes of Pandemic (H1N1) 2009 in Korean Children

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