Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging

Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging

Carbon-based “quantum” dots or carbon dots are surface-functionalized small carbon nanoparticles. For bright fluorescence emissions, the carbon nanoparticles may be surface-doped with an inorganic salt and then the same organic functionalization. In this study, carbon dots without and with the ZnS d...

Full description

Bibliographic Details
Main Authors: Cao, Li, Yang, Sheng-Tao, Wang, Xin, Luo, Pengju G., Liu, Jia-Hui, Sahu, Sushant, Liu, Yamin, Sun, Ya-Ping
Format: Online
Language:English
Published: Ivyspring International Publisher 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311233/
id pubmed-3311233
recordtype oai_dc
spelling pubmed-33112332012-03-23 Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging Cao, Li Yang, Sheng-Tao Wang, Xin Luo, Pengju G. Liu, Jia-Hui Sahu, Sushant Liu, Yamin Sun, Ya-Ping Research Paper Carbon-based “quantum” dots or carbon dots are surface-functionalized small carbon nanoparticles. For bright fluorescence emissions, the carbon nanoparticles may be surface-doped with an inorganic salt and then the same organic functionalization. In this study, carbon dots without and with the ZnS doping were prepared, followed by gel-column fractionation to harvest dots of 40% and 60% in fluorescence quantum yields, respectively. These highly fluorescent carbon dots were evaluated for optical imaging in mice, from which bright fluorescence images were obtained. Of particular interest was the observed competitive performance of the carbon dots in vivo to that of the well-established CdSe/ZnS QDs. The results suggest that carbon dots may be further developed into a new class of high-performance yet nontoxic contrast agents for optical bioimaging. Ivyspring International Publisher 2012-03-07 /pmc/articles/PMC3311233/ /pubmed/22448196 http://dx.doi.org/10.7150/thno.3912 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Cao, Li
Yang, Sheng-Tao
Wang, Xin
Luo, Pengju G.
Liu, Jia-Hui
Sahu, Sushant
Liu, Yamin
Sun, Ya-Ping
spellingShingle Cao, Li
Yang, Sheng-Tao
Wang, Xin
Luo, Pengju G.
Liu, Jia-Hui
Sahu, Sushant
Liu, Yamin
Sun, Ya-Ping
Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging
author_facet Cao, Li
Yang, Sheng-Tao
Wang, Xin
Luo, Pengju G.
Liu, Jia-Hui
Sahu, Sushant
Liu, Yamin
Sun, Ya-Ping
author_sort Cao, Li
title Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging
title_short Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging
title_full Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging
title_fullStr Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging
title_full_unstemmed Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging
title_sort competitive performance of carbon “quantum” dots in optical bioimaging
description Carbon-based “quantum” dots or carbon dots are surface-functionalized small carbon nanoparticles. For bright fluorescence emissions, the carbon nanoparticles may be surface-doped with an inorganic salt and then the same organic functionalization. In this study, carbon dots without and with the ZnS doping were prepared, followed by gel-column fractionation to harvest dots of 40% and 60% in fluorescence quantum yields, respectively. These highly fluorescent carbon dots were evaluated for optical imaging in mice, from which bright fluorescence images were obtained. Of particular interest was the observed competitive performance of the carbon dots in vivo to that of the well-established CdSe/ZnS QDs. The results suggest that carbon dots may be further developed into a new class of high-performance yet nontoxic contrast agents for optical bioimaging.
publisher Ivyspring International Publisher
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311233/
_version_ 1611516482866380800

Similar Items