Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder

Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder

Neuroplasticity may have a core role in the pathophysiology of major depressive disorder (MDD), a concept supported by experimental studies that found that excessive cortisol secretion and/or excessive production of inflammatory cytokines impairs neuronal plasticity and neurogenesis in the hippocamp...

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Bibliographic Details
Main Authors: Frodl, T, Carballedo, A, Hughes, M M, Saleh, K, Fagan, A, Skokauskas, N, McLoughlin, D M, Meaney, J, O'Keane, V, Connor, T J
Format: Online
Language:English
Published: Nature Publishing Group 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309536/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309536/

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