The evolution of metazoan extracellular matrix
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone...
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| Format: | Online |
| Language: | English |
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The Rockefeller University Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308698/ |
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pubmed-3308698 |
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pubmed-33086982012-09-19 The evolution of metazoan extracellular matrix Hynes, Richard O. Reviews The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa. The Rockefeller University Press 2012-03-19 /pmc/articles/PMC3308698/ /pubmed/22431747 http://dx.doi.org/10.1083/jcb.201109041 Text en © 2012 Hynes This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Hynes, Richard O. |
| spellingShingle |
Hynes, Richard O. The evolution of metazoan extracellular matrix |
| author_facet |
Hynes, Richard O. |
| author_sort |
Hynes, Richard O. |
| title |
The evolution of metazoan extracellular matrix |
| title_short |
The evolution of metazoan extracellular matrix |
| title_full |
The evolution of metazoan extracellular matrix |
| title_fullStr |
The evolution of metazoan extracellular matrix |
| title_full_unstemmed |
The evolution of metazoan extracellular matrix |
| title_sort |
evolution of metazoan extracellular matrix |
| description |
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa. |
| publisher |
The Rockefeller University Press |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308698/ |
| _version_ |
1611515665254973440 |