In vivo three-dimensional optical coherence elastography◊

Abstract: We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously rep...

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Bibliographic Details
Main Authors: Kennedy, Brendan F., Liang, Xing, Adie, Steven G., Gerstmann, Derek K., Quirk, Bryden C., Boppart, Stephen A., Sampson, David D.
Format: Online
Language:English
Published: Optical Society of America 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308196/
Description
Summary:Abstract: We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case.