Highly Sensitive and Specific Detection of Rare Variants in Mixed Viral Populations from Massively Parallel Sequence Data

Highly Sensitive and Specific Detection of Rare Variants in Mixed Viral Populations from Massively Parallel Sequence Data

Viruses diversify over time within hosts, often undercutting the effectiveness of host defenses and therapeutic interventions. To design successful vaccines and therapeutics, it is critical to better understand viral diversification, including comprehensively characterizing the genetic variants in v...

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Bibliographic Details
Main Authors: Macalalad, Alexander R., Zody, Michael C., Charlebois, Patrick, Lennon, Niall J., Newman, Ruchi M., Malboeuf, Christine M., Ryan, Elizabeth M., Boutwell, Christian L., Power, Karen A., Brackney, Doug E., Pesko, Kendra N., Levin, Joshua Z., Ebel, Gregory D., Allen, Todd M., Birren, Bruce W., Henn, Matthew R.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305335/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305335/

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